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Volume 37 , Issue 3
May/June 2017
Pages 393–401

Periodontal Regenerative Therapy of Intrabony Defects Using Deproteinized Bovine Bone Mineral in Combination with Collagen Barrier Membrane: A Multicenter Prospective Case-Series Study

Daisuke Irokawa, DDS, PhD/Nobuki Okubo, DDS, PhD/Masahiko Nikaido, DDS/Hiroyasu Shimizu, DDS/Hiroyuki Konobu, DDS, PhD/Tokuo Matsui, DDS/Takahisa Fujita, DDS, PhD/Hiroaki Goto, DDS/Takahiro Takeuchi, DDS, PhD/Yoshihito Ishii, DDS, PhD/Atsushi Saito, DDS, PhD

PMID: 28196153
DOI: 10.11607/prd.2888

This multicenter prospective case series study aimed to evaluate the outcome of periodontal regenerative therapy using a deproteinized bovine bone mineral (DBBM) in combination with a collagen barrier (CB) in the treatment of intrabony defects. A total of 36 nonsmoking patients with chronic periodontitis were recruited in five centers in Japan. All patients had at least one intrabony defect of ≥ 3 mm. The surgical procedures included access for debridement using a papilla preservation technique. Defects were filled with DBBM and covered with CB. Clinical evidence after 6 months supported the effectiveness of the combination therapy in the treatment of intrabony defects.

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